Автор(ы): Meyramov G. G.*Kohnert K. D.*Tykezhanova G. M.*Kystaubaеva Z. T.*Kikimbaeva A. A.*Aitkulov A. M.*Dupont O. N.*Laryushina Ye. M.*Abdraimova-Meyramova A. G.*Abdulina G. A.*Akhmetova S. B.*Shaybek A. S.*Kovalenko O. L.*

Объем документа: С. 21-29

МРНТИ: 76.29.37*

Ключевые слова: гистохимическое и иммуноцитогистохимическое исследование*

Реферат: Authors showed that intravenous injection amino acids Cystein and L-Hystidine prevent in majority of animals developing of experimental diabetes caused by chemicals formed in B-cells chelat complexes with Zn+2-ions. It was shown that in all cases administration of these amino acids prior injection of diabetogenic chelator as Diphe nylthiocarbazon (Dithizon) accompanied by almost complete absence of binding of Zn+2-ions in В-cells with formation of toxic complexes which result destruction and death of B-cells within short time. Authors suppose that protective effect is determined by presence in molecules of Cystein and L Hystidine of SH-groups reacted with reacted with Zn+2-ions in B-cells with forming of not toxic complexes and not able to forming of complexes with a Dithizon. Authors showed also that from the used various histochemical and immunocytohistochemical methods insulin staining in B-cell more precise results was obtained using of immunohistochemical and fluorescent Diethylpseudoisocyanine methods. However, Aldehyde- fuchsine method and method Victoria 4R more suitable for investigation state of histostructure of pancreatic islets.

Автор(ы): Meyramov G. G.*Kohnert K. D.*Vogt L.*Kystaubaeva Z. T.*Tykezhanova G. M.*Tusupbekova G. T.*Mindubaeva F. A.*Zhuzbaeva G. O.*Shaybek A. S.*Zhumagalieva Z. Z.*Tyrzhanova S. S.*Zhumasheva K. A.*Kaibogarova A.*

Объем документа: С. 30-33

МРНТИ: 76.29.37*

Ключевые слова: диабет*медицина*

Реферат: 2,3-Dimercaptopropanol is a substance able to re-activate sulfhydryl groups of enzymes and has the property to form temporary complexes with metals, including zinc. It is also known that certain amino acids, particularly cysteine and glutathione also contain in its composition mole coli SH-groups. Administration of these amino acids in to animals result prevention developing of experimental diabetes caused zinkbinding diabetogenic chemicals. It is confirmed that this effect is determined by their ability to form non-toxic temporary complexes with zinc in B-cells of pancreatic islets that protect cells of the destruction caused by diabetogenic chelating agents. The authors have shown that 2,3-dimercaptopropanol at doses of 60 and 120 mg/kg is able to prevent the development of diabetes in almost all experimental animals. Authors found that this ability 2,3-dimercaptopropanol is explained by its property through SH-groups included in its composition, to form non-toxic complexes with zinc in pancreatic cells that protect cells of death.

Автор(ы): Chlup R.*

Объем документа: С. 34-50

МРНТИ: 76.29.37*

Ключевые слова: клинические исследования*медицина*

Реферат: This paper summarizes results of clinical studies in the period of years 1971-2014 as follows: (1) In persons with type 1 diabetes, effectiveness of conventional therapy with multiple doses of shortacting insulin (MDI) or continuous sucutaneous insulin infusion (CSII) was demonstrated. Dynamic training was shown to enhance insulin sensitivity and plasma HDL cholesterol, and to improve neuropathy, memory and attention. Influence of alcohol and effects of insulin on postprandial alcohol concentrations revealed similar consequences; model experiments were suggested when answering forensic questions. (2) In persons with type 2 diabetes, advantage of complementary therapy with prandial rapid acting insulin was demonstrated. In MDIpersistent hyperglycaemia, insulin pump was shown to reduce HbA1c, to diminish daily insulin dose and to improve quality of life. Benefits of incretin preparations were described. Effects of losartan on renal and cardiovascular outcomes in diabetic nephropathy were documented. (3) Perinatal mortality of newborns of mothers with diabetes decreased due to thorough diabetes and obstetric care. (4) Manual Device for Insulin injections (MADI-pen) was developed and introduced into daily routine. Its accuracy, pharmacological and microbial safety were proved. (5) <Programmed Treatment of persons with diabetes> comprising the principels of Therapeutic Patients Education of the WHO was introduced. (6) Glycaemic Index of foods was calculated using a new method with continuous glucose monitoring. (7) Intensive selfmonitoring. The accuracy and precision of various glucometers were explored. Tenpoint ambulatory glycaemic profile and continuous glucose monitoring system (CGMS) was introduced to practice. In persons on insulin pumps CGMS resulted in reduction of HBA1c.

Автор(ы): Kikimbaeva A. A.*Kystaubaeva Z. T.*Tykezhanova G. M.*Bystrevska L. K.*Abdraimova-Meyramova A. G.*Laryushina Ye. M.*Zhautikova S. B.*Beskov V. N.*Zhuzbaeva G. O.*Alina A. R.*Turzhanova S. S.*Turlibekova G. K.*

Объем документа: С. 51-55

МРНТИ: 76.13.17*

Ключевые слова: гистохимический метод*медицина*

Реферат: It is showed by authors that using of 8-para(toluenesulphonylamino)quinoline - a derivative of 8-oxyquinolin result histochemical revealing by using of fluorescent microscopy of Zn+2-ions in cells of tissue of prostate, in pancreatic B-cells and in salivary glands contains a large amounts of ions. This method is high sensitive and high specific for revealing of Zn+2-ions and there are only one step of staining procedures. Meanwhile it is possible to use only fresh frozen sections of tissues for investigation within short time limited by 15-20 min.

Автор(ы): Alina A. R.*Turgunova L. G.*Laryushina Ye. M.*Vasilyeva N. V.*Amirkhanova D. T.*

Объем документа: С. 56-63

МРНТИ: 76.29.37*

Ключевые слова: сахарный диабет*медицина*

Реферат: Purpose of the research - to study the frequency of occurrence of polymorphism ST gene methylenetetrahydrofolate patients with diabetes mellitus type 2 and its correlation with homocysteine levels and the development of ischemic heart diseases. 118 patients with diabetes mellitus type 2 at the age of 45-60 years were surveyed. Statistically significant differences were observed frequencies of alleles of T and S, genotype SS between groups of patients with pancreatic diabetes type 2 with ischemic heart disease and tran- sferred myocardial infarction and healthy persons. It was found that the allele T 677 gene, methylentetrahydrofolatreductase associated with an increased risk of myocardial infarction in patients with diabetes mellitus type 2 (OR=1,879, p=0,029). The combination of genotype T677 gene methylenetetrahydrofolatereductase with hyperhomocysteinemia in 2 type diabetic patients with coronary heart disease is related with other risk factors for cardiovascular diseases and can have a significant impact on the course of ischemic heart disease.

Автор(ы): Turmuchambetova A. A.*Turgunova L. G.*Amirkhanova D. T.*Laryushina E. M.*Alina A. R.*Zhakupova A. E.*

Объем документа: С. 64-69

МРНТИ: 76.29.37*

Ключевые слова: сахарный диабет*медицина*

Реферат: We studied the frequency and structure of the risk factors of diabetes mellitus in 1453 respondents Karaganda region in the form of screening among urban and rural population using a scale FINDRISK. To identify factors shaping the development of the high risk of diabetes, was conducted the analysis of the socio-economic conditions, lifestyle factors, presence of chronic diseases, as well as a number of quantitative indicators such as: body mass index, waist circumference, measurement of glucose levels and blood cholesterol. The presence of high frequency (99,5 %) risk of developing diabetes among urban populations (46,3 %) and villages of the Karaganda region (53,6 %) in the age group from 45 to 60 years. It is revealed that a high risk of developing diabetes is higher by a factor of 1.2 in the urban population of Karaganda region than in rural areas. Risk factors that determine the high-risk group, as in the urban population, and in rural areas are lack of employment, presence of hypertension, angina, lack of physical activity, passive smoking, obesity, hyperglycemia, hypercholesterolemia.

Автор(ы): Najmutdinova D. K.*Kudratova N. A.*

Объем документа: С. 70-77

МРНТИ: 76.29.37*

Ключевые слова: сахарный диабет*медицина*

Реферат: We have investigated 20 patients with type 2 diabetes, with an average age of 58,0 + 4,32 years, with disease duration of 6,29 + 1,28 years. The carbohydrate metabolism was estimated: fasting blood glucose and 2 hours later after meal, glycosylated hemoglobin (HbA1C). For the purpose of determine the safety of insulin analogues, have been studied biochemical parameters of blood before and after 3 months of therapy. The basic criterion of the safety of the therapy within 3 months of application study of insulin analogues was the number of daytime and nighttime hypoglycaemia, as well as the dynamics of body weight during the study period. Structural and functional state of the left parts of heart was assessed by echocardiography and dopplerography of transmitral blood flow. For all patients were assigned insulin analogues, the average daily dose was 32,4 + 2,8 units, particularly rapid-acting insulin aspart (Novorapid) and acting insulin detemir (Levemir). Analogs of human insulin had a favorable effect on carbohydrate metabolism and reduced the incidence of nocturnal hypoglycemia. Also, there was a trend to improvement of the structural parameters and left ventricular diastolic function in patients with type 2 diabetes after treatment with insulin analogues. Application of insulin analogues have proven the safety of the insulin group in terms of prevention of hypoglycemia, which has a positive effect on cardiovascular events in the outcome of the treatment of diabetes.

Автор(ы): Turmuchambetova A. A.*Turgunova L. G.*Laryushina Ye. M.*Amirkhanova D. T.*Alina A. R.*Koichubekov B. K.*Zhakupova A. E.*

Объем документа: С. 78-80

МРНТИ: 76.29.36*

Ключевые слова: сахарный диабет*медицина*

Реферат: There was conducted investigation of the nephritic blood circulations in different levels of the nephritic arteries of 90 patients with the 2nd type of diabetes in combination with the chronic pyelo-nephritis in the phase of exacerbation and remission. There was determined disorder of the nephritic blood circulations in the form of the nephritic blood flow velocity lowering and the increasing of the nephritic vascular resistance in different levels of the nephritic arteries, the expressiveness of which is determined by the activity of the inflammatory process in kidneys.

Автор(ы): Zernke B.*Mukasheva M. A.*Mukasheva G. Zh.*Tykezhanova G. M.*Kazimova A. E.*

Объем документа: С. 4-8

МРНТИ: 87.03*

Ключевые слова: экология*биология*

Реферат: The questions on the ecological projects with use of methodology of an estimation of risk and economic efficiency are surveyed at acceptance of the decisions about unhealthy industrial emissions. Thus it is necessary to give attention to systems of long-term observations including: research of spatial - temporary distribution of chemical substance; optimization of a network of observation; optimization of parameters and agents of observation; automation of system of monitoring; organization of flows of the information reports.

Автор(ы): Konkabaeva А. Е.*Baranova T. I.*Tykezhanova G. M.*Nurlybaeva K. A.*Кanafina B. A.*Bugembaeva A. T.*Rasol M.*

Объем документа: С. 9-14

МРНТИ: 76.29.30*

Ключевые слова: Сравнительная оценка*биология*

Реферат: The article presents the results of survey of two groups of male students (mean age 20 + 2) from the Department of Physical Culture and Sports as well as the biology and geography departments. The heart rate variability was examined using a computerized complex <Varikard> (Russia). Estimation of heart rate variability was performed using mathematical statistics method of R.M.Baevsky. Cardiovascular system\'s fitness was estimated by determining the type of response to the diving reflex using the method of cold-hypoxiahypercanic effect (CHE). There was a substantial stress and strain of regulatory systems at the majority of students of the Faculty of Physical Education and Sport, what shows a decline of adaptive reserves of the body, caused by excessive loads.